Our focus is on the endoderm, the progenitor tissue that gives rise to respiratory and digestive tracts, and associated organs such as the lung, liver and pancreas. Our overarching goal is to ...

In a new study published in eLife, the researchers focused on the outermost visceral endoderm cells of mouse embryos. By ...

To treat his impaired islet cell function, the research team generated functional islet-like clusters, called “E-islets,” from the patient’s own endoderm stem cells derived from blood cells.

Further cell divisions lead to the formation of the primitive endoderm, which forms a blastocyst. This structure implants around one week after fertilization. As development continues, the epiblast ...

After exposure to trans-retinoic acid, these cells can develop into two distinct forms of extra-embryonic endoderm. To date, differential library screening has been the best tool available to ...

Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration.