编辑推荐： 本研究针对GSTM1和GSTT1基因缺失多态性与多发性骨髓瘤 (MM)发病风险的争议性问题，通过系统评价4项研究共1131例样本，首次证实GSTM1缺失可降低MM风险 (OR=0.66)，而GSTT1缺失显著增加风险 (OR=1.60)。该Meta分析为MM的遗传易感性机制提供了新证据，对高危人群筛查具有重要临床意义。

GSTM1和GSTT1无效多态性是OSMF的独立遗传风险因子，其与槟榔暴露的协同效应显著加剧疾病发生及进展。 整合遗传筛查与行为干预（如槟榔戒断），可为南亚高发区提供精准预防策略，阻断"纤维化-癌变"进程。

Our results suggested that the polymorphisms of GSTT1 and GSTM1 were associated with the methylation of arsenic, especially the levels of DMA and SMI.

Glutathione S-transferase Theta1 and Mu1 (GSTT1 and GSTM1) are involved in the metabolism and detoxification of a wide range of potential environmental carcinogens.

Polymorphisms of GSTP1, GSTT1, GSTM1, MTHFR, TS, ERCC1, and ERCC2 in metastatic colorectal cancer treated by first-line mFOLFOX6 chemotherapy. If you have the appropriate software installed, you can ...

The non-null GSTT1 allele was associated with lower category mammographic findings. Prospective clinical evaluation of the women followed in this program and correlation of genotype with clinical ...