Department of Pharmaceutical and Cell Biological Chemistry, Pharmaceutical Institute, University of Bonn, 53121 Bonn, Germany ...

Center for Biopharmaceuticals and Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, DK-2100 Copenhagen, Denmark ...

Furthermore, recent studies have shown a therapeutic role for histone deacetylase inhibitors in a number of HD models. In this review, we summarize the current state of knowledge regarding the ...

This is the first comprehensive immunohistochemical analysis of the expression of several class I HDAC proteins (1, 2 and 3) in urothelial carcinoma. In our study, we found all three isoforms in a ...

The company’s pipeline products also include VTR-297, a small molecule histone deacetylase inhibitor to treat hematologic malignancies and with potential use as a treatment for various oncology ...

These dynamic processes involve significant alterations in gene expression profiles within the endometrium and trophoblast lineages. Epigenetics regulatory mechanisms, such as DNA methylation, histone ...

探究 HDAC8 抑制剂结合机制与远程调控，助力靶向药物研发 近日，中山大学药学院（第一作者单位）的研究人员 Yuxiang Luo 等人在《Communications Biology》期刊上发表了题为 “Binding mechanism and distant regulation of histone deacetylase 8 by PCI-34051” 的论文。这一研究成果在癌症 ...

These results suggest that chemical modification of DNA and histone is promoted in female CSM snails, although the histone deacetylase 8 was up-regulated in CSM snails. 4.6 Relevance of the nuclear ...

The modification, effective February 1, 2025, was disclosed in a recent 8-K filing with the Securities ... secured a patent for selective histone deacetylase (HDAC) inhibitors, contributing ...