During the process of reprogramming to induced pluripotent stem (iPS) cells, somatic cells switch from oxidative to glycolytic metabolism, a transition associated with profound mitochondrial ...

Notably, SIRT1OE appears to enhance metabolic switch at day 6 (Supplementary Fig. 8h), which is likely due to an indirect effect by enhancing the reprogramming process (Supplementary Fig. 8e, f).

Heart tissue normally can't regenerate after an injury. But now, scientists at Max Planck have shown in mice that reprogramming the energy metabolism of the heart allows it to regenerate after a ...

Induced pluripotent stem (iPS) cells are obtained by reprogramming somatic cells. This powerful disease-modeling research tool is central to certain experimental approaches to therapy. A recent stu ...

Induced pluripotent stem (iPS) cell reprogramming allows turning an adult somatic cell into a pluripotent stem cell. Four Factor pluripotency reprogramming of somatic cells and subsequent ...

To study this metabolic switch, the authors injected B16F10 cells tagged with a fluorescent marker ... These results suggested that tumor-derived microparticles induce macrophage metabolic ...

In the process we shed new light on the mechanism of making iPS cells." The challenge with the previous method – OSKM – has been that very few cells actually become iPS cells during reprogramming.

A Ludwig Cancer Research study has identified a metabolic switch in the immune system's T cells that is essential to the generation of memory T cells—which confer lasting immunity to previously ...

Current methodologies for the detection of inducible Pluripotent Stem (iPS) reprogramming are either disruptive e.g. flow cytometry (FC) or low in throughput e.g. fluorescent microscopy (FM). Using ...

Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...