Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and ...

The functional alteration of nucleus pulposus cells (NPCs) exerts a crucial role in the occurrence and progression of intervertebral disk degeneration (IDD). Circular RNAs and microRNAs (miRs) are ...

Many aspects of the physiology of the intervertebral disc (IVD) show clear diurnal rhythms. However, it is unknown whether IVD tissue contains functional circadian clocks and if so, how their ...

Underscores high unmet need for a therapeutic alternative to opioids and surgical interventions – – Reflects positive ...

为解决椎间盘退变临床诊断和疗效评估难题，南京中医药大学中西医结合附属医院的研究人员，开展 DTI 参数与退变椎间盘生化成分相关性研究。结果发现二者存在显著关联。该研究为临床诊断和疗效评估提供新参考，值得一读。

腰痛已成为全球性的重大健康问题，给社会带来了沉重的经济负担，并且随着人口老龄化的加剧，这一问题愈发严重。众多研究表明，腰痛与椎间盘退变密切相关。椎间盘退变过程中，髓核细胞（nucleus pulposus cells，NPCs）和细胞外基质（extracellular matrix，ECM）会逐渐流失。细胞外基质主要由胶原纤维和蛋白聚糖（如聚集蛋白聚糖）组成，主要由髓核细胞产生并维持，其中 ...

Objectives Lumbar disc degeneration (LDD) is prevalent, age-related and contributes to low back pain. Cross-sectional LDD as determined by MRI scan is known to be highly heritable. The authors ...

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As pet owners, we want our furry companions to live long, happy, and pain-free lives. While traditional veterinary care is essential, complementary treatments like veterinary chiropractic care are ...