Objectives Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous autoimmune diseases. Intron retention (IR) serves as an important post-transcriptional and translational regulatory ...

nus.edu.sg Objective An unmet need exists for a non-invasive biomarker assay to aid gastric cancer diagnosis. We aimed to develop a serum microRNA (miRNA) panel for identifying patients with all ...

Encouragingly, the concept of miRNA-based therapeutics is developing, with synthetic antagonists of miRNAs (antagomiRs) currently in phase II trials for the treatment of chronic hepatitis C virus ...

Plant genomes can spawn new microRNA (miRNA)-generating loci de novo by inverted duplication of protein-coding sequences followed by accommodation by the specialized miRNA-biogenesis apparatus ...

They are critical regulators of organism development, cell differentiation, metabolism, and apoptosis. Current clinical trials on miRNA drugs indicate that patient-specific miRNA levels are now being ...

The miRNA-loaded RISC combines with the reverse complementary sequence within the 3′UTR of the target mRNA, suppressing the translation or degradation of the target mRNA. FIGURE 2. Biogenesis of ...