敲低 Parkin 后，检测 PFV Gag 过表达细胞中线粒体蛋白 Cox4 和 Tom20 的水平，发现 Cox4 和 Tom20 的减少得到逆转，同时 LC3 和 Tom20 的共定位也减少。 这些结果表明，PFV Gag 诱导的 mitophagy 依赖于 Parkin。

编辑推荐： 免疫应答中，白细胞整合素 LFA1对淋巴细胞运输和黏附至关重要，但其激活后在细胞接触表面聚集的调控机制不明。研究人员探究自噬成分 LC3 与 LFA1运输的关系，发现 LC3 可调节 LFA1在接触表面的积累和淋巴细胞黏附，拓展了对淋巴细胞调控的认知。

The LC3-Skifter is a unique item needed to unlock one of the more useful abilities in Star Wars Outlaws. The LC3-Skifter can only be found in one place, so the guide below will tell you what it ...

The Q311X mutation is a nonsense mutation that produces a C-terminally truncated parkin, just 155 amino acids long. Parkin-Q311X mice (line A) have two copies of the transgene (Tg) integrated in ...

LC3 II/LC3 I ratio, PINK1, parkin and c-caspase-3 protein expression were significantly increased, while the expression level of P62 was significantly decreased in MIRI group or AP13-treated MIRI ...

非泛素化依赖通路主要由自噬受体介导，它们不经泛素化直接与LC3结合，从而启动线粒体自噬。FUNDC1可通过与LC3相互作用诱导低氧下哺乳动物细胞的线粒体自噬。FUNDC1介导的线粒体自噬不依赖于Parkin，… ...

Boosters for a more sustainably produced cement, which slashes greenhouse gas emissions up to 40% compared to ordinary portland cement production, say the material, called limestone calcined clay ...

Here, we report that Parkin activates lipid remodeling on mitochondria targeted for autophagic destruction. Mitochondrial Parkin induces the production of phosphatidic acid (PA) and its subsequent ...