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Objectives Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s ...
The structure of sialic acid on living cells can be modulated by metabolism of unnatural biosynthetic precursors. Here we investigate the conversion of a panel of azide-functionalized mannosamine and ...
While single reactions and metabolic pathways have been studied in detail, it has been painstaking to determine which are active or "carry flux" in a given cell at a given moment.
Synopsis Enhanced flux potential analysis (eFPA) predicts relative fluxes of metabolic reactions using proteomic or transcriptomic data. It achieves optimal predictions by integrating expression data ...
They successfully predicted metabolic reactions beneficial to cell growth, with high convergence between the models. The models revealed that biosynthetic pathways generally promote growth across ...
Whole-Exome Sequencing for Identification of Genetic Variants Involved in Vitamin D Metabolic Pathways in Families With Vitamin D Deficiency in Saudi Arabia ...
The inverse electron-demand Diels-Alder (IEDDA or DA inv) reaction is an emerging bioorthogonal ligation reaction that finds application in all areas of chemistry and chemical biology. In this review ...
Metabolism, including cellular respiration, encompasses a large component of the topics covered in foundational biochemistry and life science undergraduate courses. The difficulty in instruction and ...
Background: Sphingolipids have recently emerged as a biomarker of recurrence and mortality after myocardial infarction (MI). The increased ceramide levels in mammalian heart tissues during acute MI, ...
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