Introduction: Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a crucial regulator of immune responses, particularly within microglia, where it may influence the infiltration of peripheral T ...

Microglia play a crucial role in neuroinflammation after ischemic brain injury. Previous data have shown that leukocyte immunoglobulin-like receptor B4 (LILRB4) was upregulated in mice after middle ...

Objective: Microglia, the central nervous system's immune cells, are crucial in neuroinflammation after ischemic brain injury. Previous single-cell and spatial transcriptomics showed that LILRB4 was ...

研究人员使用携带人类LILRB4转基因且具有淀粉样蛋白（A）沉积的小鼠模型，通过LILRB4靶向单抗进行干预时发现：LILRB4单抗可降低A积累并减轻A相关的行为异常；LILRB4单抗增强了小胶质细胞活性；减少干扰素诱导基因的表达，可以减轻神经炎症。

One study explored the function of LILRB4, a member of the LILR family, in macrophages. It was found that LILRB4 can co-tether fibronectin with integrins on macrophages, suggesting a mechanism by ...

格隆汇2月19日丨德琪医药-B(06996.HK)发布公告，公司计划加大投入，整合资源成立专门的AI部门。这一举措包括本地部署DeepSeek以加速具有空间位元阻遮蔽效应的T细胞衔接器(TCE)平台后续管线研发。公司早在2021年便以天使投资人身份投 ...

LILRB4 ligation by APOE on monocytic AML cells mediates SHP-2 inhibitory signalling, which in turn positively regulate the NF-κB pathway. This leads to ARG1 production and urokinase-type plasminogen ...

智通财经APP讯，德琪医药-B (06996)发布公告，公司计划加大投入，整合资源成立专门的AI部门。这一举措包括本地部署DeepSeek以加速具有空间位元阻遮蔽效应的T细胞衔接器 (TCE)平台后续管线研发。

除ATG-201以外，公司的TCE管线还包括ATG-102，一款用于急性髓系白血病和慢性粒单核细胞白血病的LILRB4 x CD3 TCE;ATG-106，一款用于卵巢癌和肾癌的CDH6 x CD3 ...