“The unexpected link between saposin-mediated glycosphingolipid degradation, iron metabolism, lipofuscin accumulation, and oxidative stress underscores an important role of lysosomes in regulating ...

When the scientists added tau seeds to iPSC-derived neurons exposed to a variety of ApoE lipoprotein particles, lipofuscin formation and tau fibril internalization went hand-in-hand, with cells ...

Using postmortem tissues, Gan's team found that lipofuscin deposits also accumulated in neurons from the frontal cortex of people carrying progranulin mutations.