Asthma a chronic respiratory condition may be driven by specific immune cells that influence inflammation and severity ...

8). Figure 8: Strategies to inhibit the allergic response underlying asthma. Anti-IgE. The release of mediators from mast cells in asthma is IgE-dependent, and blocking the activation of IgE using ...

Asthma is a T helper 2 (T H 2)-cell-mediated disorder characterized by airway eosinophilia, goblet-cell hyperplasia and bronchial hyper-reactivity. Dendritic cells (DCs) sample the airway luminal ...

Previous research indicates that mast cells, a type of immune cell found in the tissues throughout the body, cause ...

J Med Genet., 42, e36 Evidence suggests that mast cells play a central role in the pathophysiology of asthma. Mast cells act as sensors of the environment to defend against damage and infection. They ...

Jasper Therapeutics, Inc. (Nasdaq: JSPR) (Jasper), a clinical stage biotechnology company focused on development of ...

4. Broader efficacy across indications: Success in multiple indications such as CSU, CIndU, and potentially asthma could establish briquilimab as a versatile treatment option, capturing a larger share ...

especially from mast cells. Increased risk of asthma-related events (death, hospitalizations, intubations) with LABA monotherapy (without ICS). Do not initiate in rapidly or acutely deteriorating ...

leading to the depletion of the mast cells via apoptosis which removes the underlying source of the inflammatory response in mast cell driven diseases such as chronic urticaria and asthma. Jasper is ...