在全球范围内，结直肠癌（CRC）是导致癌症相关死亡的主要原因之一。近年来，随着 CRC 筛查项目的广泛开展以及内镜成像技术的进步，T1 期结直肠癌（一种侵犯黏膜下层的病变）的诊断数量显著增加。这一变化促使临床治疗 T1 期 CRC 的方式发生了转变。

此外，近年来可变多聚腺苷酸化（Alternative polyadenylation，APA）作为基因表达调控的关键机制受到关注。APA 可以影响 RNA 3’端的形成，进而影响 RNA 的稳定性、核糖体加载和翻译效率，这些过程都与疾病的发展密切相关。例如，甲型流感病毒（IAV）菌株能诱导宿主细胞发生 APA，参与抗病毒反应，而 APA 的缺失会导致小鼠炎症反应增加和毒力降低，表明 APA ...

Fifth Subject in BB-301 Phase 1b/2a Clinical Treatment Study safely treated in February 2025- -Interim clinical study update to be presented in late-breaking oral presentation at the 2025 Muscular Dys ...

On March 18 th Jerel A. Banks, M.D., Ph.D., Executive Chairman and Chief Executive Officer of Benitec will be giving an oral presentation in the first session dedicated to OPMD at the 2025 Muscular ...

CRISPR/Cas9 works using a Cas9 enzyme and a guide RNA. Lau compared the guide RNA ... DNA sequences and blocks protein production and gene expression. According to Qi, the fact that this method ...

For the current study, they began by evaluating the epithelial factor ESRP2, a regulatory protein known to control RNA splicing in the liver ... "We have noticed that post-transcriptional regulation ...

For the current study, they began by evaluating the epithelial factor ESRP2, a regulatory protein known to control RNA splicing in ... tunes the final phases of gene expression," Kalsotra said.

In a new study led by graduate student Ike Emerson in the Conlon lab, researchers discovered that a microRNA called miR-871 ... in biology can be established after a gene is turned on." MicroRNAs are ...

Many relevant examples have proved that miRNA inhibits viral proliferation and replication by targeting viral RNA and gene silencing. For example, the infectious bursal disease virus (IBDV), a member ...

cleaving pre-miRNAs into miRNA duplexes (see figure 1) Drosha: an RNase enzyme that, in combination with DGCR8, cleaves primary miRNAs into stem-loop precursor miRNAs (see figure 1) MicroRNAs: small, ...

In a new study led by graduate student Ike Emerson in the Conlon lab, researchers discovered that a microRNA called ... a crucial role in regulating gene expression, effectively turning genes ...

2 Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China 3 State Key Laboratory of Liver Research, Li Ka Shing Faculty of Medicine, University of ...