For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these ...

Self-supervised pretraining attempts to enhance model performance by obtaining effective features from unlabeled data, and has demonstrated its effectiveness in the field of histopathology images.

Automatic cell/nucleus detection is a prerequisite for various quantitative analyses on microscopy image. However, previous deep learning methods require enough annotated microscopy images for better ...

Vaccines have been rigorously tested, reviewed, and monitored for decades. They are one of the greatest success stories in ...

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought.

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical ...

Yet, the remaining challenge toward optimizing PM-based mRNA delivery systems for systemic application is to build a functionality to prevent RNase invasion into the polyplex core storing cargo mRNA.

Are these vaccines dangerous? They do NOT change our DNA. mRNA makes a one-way trip and does not enter the nucleus or change our DNA. Yes, people can get muscle aches and fever, but this can happen ...

Fact check: HHS misleads on mRNA vaccine safety after pulling Moderna funding The safety of approved mRNA vaccines is well-established and, as with other vaccines, continues to be monitored by ...