Vitamin D, often referred to as the "sunshine vitamin", is a fat-soluble vitamin that plays a critical role in bone health, ...

As far back as 1873, Kölliker 1 observed the existence of osteoclasts in the periosteum of normal bone. Lacroix 2 also made several references to the presence of periosteal osteoclasts during ...

The enzyme aconitate decarboxylase 1 (Acod1) is known to link the cellular function of monocyte-derived macrophages to their metabolic status. As osteoclasts derive from the monocyte lineage, we ...

The disease occurs when there's an imbalance between a person's osteoblasts – which are bone-building cells – and their osteoclasts, which are bone-degrading cells. Ordinarily, osteoclasts ...

They observed that Fam102a promoted the differentiation of both osteoclasts and osteoblasts, and deletion of Fam102a resulted in an osteoporosis-like condition in mice, characterized by low bone ...

Methods: We employed a two-sample Mendelian randomization approach to assess the associations between gut microbiota with osteoclasts and postmenopausal osteoporosis, respectively. Single nucleotide ...

Medically reviewed by Renita White, MD Lower levels of estrogen in menopause can make you more vulnerable to osteoporosis.

Bone is a hard tissue with mineralized bone matrix, which renders invasion by cancer cells difficult. Activation of osteoclasts is the central cellular mechanism of osteolytic bone metastasis.