The Prescription Drug User Fee Act (PDUFA) date refers to the deadline set by the US Food and Drug Administration (FDA) for reviewing a New Drug Application (NDA) or Biologics License Application (BLA ...

Bentracimab is an investigational human monoclonal antibody fragment that binds to ticagrelor, an oral P2Y 12 platelet inhibitor, reversing its antiplatelet effects. The BLA submission is ...

In addition to their essential role in hemostasis and thrombosis, platelets also modulate inflammatory reactions and immune responses. This is achieved by specialized surface receptors as well as ...

Including more consistent referral and treatment thresholds, better use of radial access, potent P2Y 12 inhibitors, referral to cardiac rehab, statin therapy, and more aggressive management of cardiac ...

Why can we still not translate preclinical research to clinical treatments for acute strokes? Despite > 1000 successful preclinical studies, drugs, and concepts for acute stroke, only two have reached ...

Neurons, muscle cells and many other types of cells use electrical signals to exchange information and coordinate their behavior. Proteins known as calcium channels sit in the membrane that surrounds ...