In their important manuscript, Costa et al. establish an in vitro model for dorsal root ganglion (DRG) axonal asymmetry, revealing that central and peripheral axon branches have distinct patterns of ...

This paper describes a new in vitro model for DRG neurons that recapitulates several key differences between the peripheral and central branches of DRG axons in vivo. These differences include ...

Neuropathy pain is hard to ignore, often making everyday tasks feel overwhelming. Many people suffering from this condition have been told that their treatment options are limited, leaving them ...

A dramatic rise in type 2 diabetes has led to an increase in peripheral neuropathy. New research published in Nature from the lab of Clifford Woolf, led by Sara Hakim, at Boston Children's Hospital ...

Whereas small fibre neuropathy is a recognized part of FM, surprisingly little is known about large fibre neuropathy. The present study investigates the sensory and motor axonal properties using novel ...

The researchers suspected that peripheral neuropathy is caused by the immune system, so used single-cell sequencing to detect changes in immune cells near sensory neuron axons in peripheral nerves.

2012; Burté et al., 2015; Paß et al., 2021; Wang et al., 2021). Pathologies that result from direct impact from external insults to the axonal bundles include traumatic brain injury (TBI), spinal cord ...