Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a type of blood cancer that affects immune system cells. It most often affects the skin but can also involve bone marrow and other cell types.

Plasmacytoid dendritic cells (pDC) primarily function as weak antigen-presenting cells (APC), but have also been shown to express functional receptors for key elements of both the innate and adaptive ...

Background Type 1 interferons (IFN-1) are major drivers of disease activity in systemic (SLE) and cutaneous lupus erythematosus (CLE). Plasmacytoid dendritic cells (pDCs) are the major producers of ...

Introduction Plasmacytoid dendritic cells (pDCs) specialize in the production of type I interferons (IFNs) and promote antiviral immune responses following engagement of pattern recognition receptors.

Objectives Plasmacytoid dendritic cells (pDC) have been implicated in the pathogenesis of autoimmune diseases, such as scleroderma (SSc). However, this has been derived from indirect evidence using ex ...

Plasmacytoid dendritic cells (pDCs) sense virus-derived nucleic acids through Toll-like receptors (TLRs) 7 and 9 and respond with massive IFN-I production (17). Persistent viruses such as HIV (18) and ...

Plasmacytoid dendritic cells (pDC), the major source of IFNα, were activated after surgery and correlated with poor disease-free survival. Functionally, IFNα was responsible for mobilization of ...

Dendritic cells (DCs) are widely acknowledged as potent antigen-presenting cells (APCs), which are able to bridge innate and adaptive immunity. DCs can be classified into plasmacytoid DCs (pDCs) and ...

This finding may help in understanding other diseases of the pancreas, including type 1 or type 2 diabetes, in which abnormal molecular crosstalk between these two groups of cells might play a ...