In vitro reconstitution of meiotic DNA double-strand breaks: A long-standing challenge solved
In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks ...
Nature1 年
Genetic Mutation
How do mutations happen, and how do they influence the future of a species? Molecules of sickle-cell hemoglobin stick to one another, forming rigid rods. These rods cause a person's red blood ...
technologynetworks17 天
Mutations Point to Promising Drug Target in 5% of Adult Cancers
These cancers have mutations in one of two genes, FOCAD or TCC37. The finding, described today in Nature, is a new synthetic lethality — a pair of genetic changes that together kill cancer cells. The ...
Medical Xpress18 天
Mutations in two gene pairs point to a promising drug target in 5% of adult cancers
These cancers have mutations in one of two genes, FOCAD or TCC37. "These cancers are a huge unmet medical need, because we don't have effective drugs for them," said Francisca Vazquez, co-senior ...
来自MSN3 个月
Cancer-like mutations in healthy cells point to genetic origins of breast cancer
"It's striking to see cancer-like mutations happening silently and at low levels in the cells of perfectly healthy women," said lead senior author Dr. Samuel Aparicio, a professor of pathology and ...