Sodium action potentials can propagate somatofugally into the dendritic tree of cortical pyramidal neurons 1, as shown by electrophysiology and optical imaging of [Ca 2+] in brain slices (for ...

Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking interneurons in the cerebral cortex. By generating a fast stream of action potentials, PV+ interneurons provide a ...

During the development of the cortex, newly generated neurons migrate long-distances in the expanding tissue to reach their final positions. Pyramidal neurons are produced from dorsal progenitors, e.g ...

This study employed voltage imaging in the CA1 region of the mouse hippocampus during the exploration of a novel environment. The authors report synchronous activity, involving almost half of the ...

This study demonstrates the critical role of Afadin on the generation and maintenance of complex cellular layers in the mouse retina. The data are solid, which provides important insights into how ...

neura.edu.au Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder of the motor neurons in the motor cortex, brainstem and spinal cord. A combination of upper and ...

unsw.edu.au Background: Distal hereditary motor neuronopathy with pyramidal features (dHMNP) is a hereditary neurodegenerative disorder characterised by the presence of upper and lower motor neuron ...

Winner of the Paul Ehrlich and Ludwig Darmstaedter Early Career Award 2025: Tobias Ackels from University of Bonn.

The aggregates happen first in the striatal neurons and later in the cortical neurons, and they progressively worsen over time, mimicking the progression of the disease. Remarkably, HD mice ...

Departments of Neurology, Psychiatry, and Pharmacology, Columbia University Irving Medical Center, New York, New York 10032, United States Department of Molecular Therapeutics, New York State ...