SeamlessTx is addressing this challenge with a unique platform that integrates large-scale directed evolution and machine learning (ML)-driven models to predict recombinase variant activity and ...

BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart ...

One promising strategy to remuscularize the injured heart is the direct cardiac reprogramming of heart fibroblast cells into cardiomyocytes. Researchers have identified TBX20 as the key missing ...

Reprogramming involves inducing the expression of four factors, called Yamanaka factors, in cells. The factors must be expressed for 2 to 3 weeks for cells to reach pluripotency.

The ability to create stem cells from non-embryonic cells, through the process of reprogramming, lifted the ethical hindrance and is driving stem cell research in a new direction at a rapid pace. A ...

Dedifferentiation, transdifferentiation and reprogramming could all be exploited to replace lost cells and tissues. Studies are aiming to understand the molecular details of these processes and to ...

They believe that reprogramming rather than poisoning cells will be less toxic to patients. "What evidence do you have that this treatment is working?" LaPook asked.

"And this happened even when the young animals were fed a completely normal diet." The cause of this disorder seems to be a kind of "reprogramming" of the Kupffer cells in the offspring. As a result, ...

Reprogramming requests sit between necessary congressional oversight and its power of the purse, and the realities of executing a budget built on years-old estimates.