Biosynthesis can be exploited for chemical synthesis in vitro or in cells like Escherichia coli by combining substrates with enzymes using recombinant methods. Many clinically important drugs ...

DHFR is a critical enzyme in the folate cycle, downstream of the SBP, which catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF), important for DNA synthesis and methylation. These ...

The multistep synthesis and thorough characterization of C-TRV3-A provided a comprehensive understanding of its structural and physicochemical properties, establishing a robust basis for subsequent ...

School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, 6140, Wellington, New Zealand Centre for Biodiscovery, Victoria University of Wellington, PO Box 600, 6140, ...

Introduction: Diagnosing the types of malignant lymphoma could help determine the most suitable treatment, anticipate the probability of recurrence and guide long-term monitoring and follow-up care.

A recent breakthrough by researchers from Shinshu University, Japan, is changing this landscape. The team has successfully achieved the first total synthesis of inaoside A, a natural compound found in ...