Northwestern University researchers have identified structural features in engineered cell receptors that correlate with variations in receptor function. Computational protein structure prediction ...

Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve cell therapies.

Although scientists can learn a lot from cell culture and animal models, they cannot truly substitute for all parts of the human body, especially the brain. But scientists have now used human brain ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...

The outlook for T-cell malignancies remain poor due to the lack of effective therapeutic options. Chimeric antigen receptor (CAR) immunotherapy has recently shown promise in clinical trials for B ...

Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the ...

Chimeric antigen receptor T-cells targeting the CD19 antigen have achieved impressive results in patients with relapsed/refractory (R/R) B-cell malignancies, leading to their approval in the European ...

Researchers have harnessed synthetic biology to engineer chimeric antigen receptor (CAR) T cells that precisely target and destroy cancer. However, these powerful cells can also attack healthy tissues ...

The Sudan virus, a close relative of Ebola, has a fatality rate of 50% but remains poorly understood in terms of how it infects cells. Currently ... More information: Fan Bu et al, Cryo-EM structure ...

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...