each CAR T cell can recognize and lyse several tumor cells. Moreover, what supports the energy cost of synapse formation versus migration, two critical events that underlie serial killing are poorly ...
A key element of the T synapse is the specific relationship between the ring of integrin adhesion molecules and the central cluster of TCRs 3. (The location of adhesion molecules in the B cell ...
Led by first author Dr. Ahmed Gad, postdoctoral associate in Ahmed’s lab, the research team examined molecular dynamics at the immune synapse. The team biopsied the CAR T cell immunological ...
We show here active clustering of TCR–MHC molecules at the immune synapse after interaction between aAPC and T cells. This multivalent system allows identification and stimulation of antigen ...
TG Therapeutics will use MaxCyte’s technology to advance toward a clinical trial its azer-cel CAR T-cell therapy for ...
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A battle of rafts: How molecular dynamics in CAR T cells explain their cancer-killing behaviorA study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor (CAR) T cells kill cancer. Investigators from Baylor College of ...
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