A key element of the T synapse is the specific relationship between the ring of integrin adhesion molecules and the central cluster of TCRs 3. (The location of adhesion molecules in the B cell ...

We show here active clustering of TCR–MHC molecules at the immune synapse after interaction between aAPC and T cells. This multivalent system allows identification and stimulation of antigen ...

Ahmed Gad, postdoctoral associate in Ahmed’s lab, the research team examined molecular dynamics at the immune synapse. The team biopsied the CAR T cell immunological synapse by isolating the mem ...

For their most effective indications, CAR T cells are effective serial killers; each CAR T cell can recognize and lyse several tumor cells. Moreover, what supports the energy cost of synapse formation ...