KBSI researchers block TDP-43 protein aggregation using graphene quantum dots KBSI scientists enhance nerve cell protection ...

New research examining the skeletal muscle cells of patients with inclusion body myositis (IBM) has revealed that the nucleic acid-binding protein TDP-43, which is normally restricted to the ...

近日，一项发表于《Science Advances》的研究揭示了细胞应对氧化应激时，TDP-43 蛋白的重要调控机制，为治疗肌萎缩侧索硬化症（ALS）和额颞叶痴呆（FTD）等神经退行性疾病带来新希望。

The diagnostic criteria for limbic-predominant age-related TDP-43 encephalopathy (LATE) have just been published. These guidelines are an important first step in advancing clinical trials and ...

In fact, there is another common cognitive disorder with very similar symptoms, called limbic-predominant age-related TDP-43 encephalopathy — or LATE for short — that is often misdiagnosed as ...

肌萎缩侧索硬化症（Amyotrophic Lateral Sclerosis，ALS），这可是一种让人闻风丧胆的致命神经退行性疾病。尽管科研人员们已经努力研究了几十年，但它至今还是个 “无药可医” 的难题。以前，治疗 ALS 的策略非常有限，有一种叫利鲁唑（Riluzole）的药物，它的作用是降低神经元兴奋性。可这药的效果实在不咋地，只能起到一点点作用。这也让大家意识到，兴奋性毒性在 ALS ...

recognizes 43kDa TARDBP only when phosphorylated at Serines 409 and 410; stains ubiquitin-positive inclusions in FTLD-U and ALS without nuclear staining; does not stain ghost tangles and ...

Scientists are urgently seeking fluid biomarkers for frontotemporal dementia, the most common dementing illness among 40- and ...

此前的研究发现，小胶质细胞在 ALS 的发展过程中会发生变化。在疾病早期，小胶质细胞可能起到保护神经的作用，但到了晚期，它们却可能变得功能失调，甚至对神经产生毒性。而且，研究人员还发现小胶质细胞的免疫表型（即蛋白质表达模式）会随着 ALS 的发展而改变，在早期呈现出吞噬免疫表型，到晚期则转变为功能失调的免疫表型，并且这种变化与大脑中 TDP - 43 的聚集有关。然而，关于小胶质细胞的形态在 ...

The diagnostic criteria for limbic-predominant age-related TDP-43 encephalopathy (LATE) are published this month in Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association from an ...