By employing THP-1 and Jurkat NF-κB::eGFP reporter cell lines expressing specific TLRs ... TLR agonists, Pam3CSK4 for TLR2/1, FSL-1 for TLR2/6, ultrapure LPS for TLR4/MD2/CD14 and the dual TLR7 and ...

Conclusions These results describe a novel pathway where altered mitochondrial biology in JDM CD14+ monocytes lead to oxmtDNA production and stimulates ISG expression. Targeting this pathway has ...

The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor, which can be upregulated in inflammatory diseases as an amplifier of immune responses. Once activated, ...

Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand Department of Pharmacognosy and Pharmaceutical Botany, Faculty of ...

The crash occurred Wednesday just after 1 p.m. on Highway 49 and left the officer of the police unit injured. According to a THP report, the driver of a Dodge Ram 1500, 42-year-old James Dillard ...

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

The following is a news release from THP. The Tennessee Highway Patrol will be conducting a Sobriety Roadside Checkpoint on US 412 in Madison County on February 9, 2025. Impaired driving is a ...

2 Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy 3 Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy 4 Department of ...

Furthermore, delafloxacin (MIC50 0.25 mg/L) was at least 4 times more potent than other tested fluoroquinolones (MIC50 1 mg/L) against P. aeruginosa. No difference in delafloxacin activity (MIC50 0.03 ...

All data relevant to this study were created by the authors of this study. The scRNA-seq datasets have been deposited in NCBI’s Gene Expression Omnibus and are accessible through GEO Series accession ...