Trimethoprim-sulfamethoxazole (TMP-SMX) has traditionally been the first-line treatment for S. maltophilia infections. However, a comparative study found that levofloxacin, another antibiotic ...

or individual risk factors such as recent treatment with TMP/SMX). In the higher-resistance setting, a 3-day course of a fluoroquinolone or a 7-day course of nitrofurantoin is appropriate.

TMP/SMX was cost-effective only when the likelihood of MRSA infection was very high, likely due to its lack of established activity against GAS. Thus, our analysis suggests that, given our current ...