1.灵敏度高：HPF对ROS具有很高的灵敏度，能够准确反映ROS的生成情况。 2.特异性强：HPF主要对羟基自由基和过氧亚硝基阴离子等高活性氧物质具有高灵敏度，对其他物质的反应较弱。 3.应用广泛：HPF可用于检测细胞、组织和生物液体中的高活性氧。通过荧光显微 ...

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 5/542, 16000 Prague, Czech Republic ...

Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the ...

Recognition of specific antigen through the B-cell receptor (BCR) stimulates the activation of B cells, which ultimately results in the production of high-affinity antibodies and the provision of ...

On the next day, CAR T cells were labeled with 0.5 μM CFSE (carboxyfluorescein diacetate succinimidyl ester; 65-0850-84, ThermoFisher Scientific) following the manufacturer’s protocol. The labeled CAR ...

This important study addresses the idea that defective lysosomal clearance might be causal to renal dysfunction in cystinosis. With mostly solid data, the authors observe that restoring expression of ...

Advanced Materials & Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park, NG7 2RD Nottingham, U.K.

This valuable study provides in-vivo evidence that CCR4 regulates the early inflammatory response during atherosclerotic plaque formation. The authors propose that altered T-cell response plays a role ...