Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States ...

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为解决 C4′ 修饰核苷合成及相关反应非对映选择性问题，西蒙弗雷泽大学研究人员研究格氏反应中卤化物效应。结果发现其可调控反应选择性并用于合成 D 构型核苷。该成果助力药物研发，强烈推荐科研读者阅读。

Figure 1. General reaction and proposed mechanism of the Yamaguchi coupling reaction.