eIF4E 家族的自然多样性 在众多真核生物中，eIF4E 异构体存在广泛的自然多样性。 不同物种的 eIF4E 异构体在氨基酸序列、表达水平和组织分布上都有所差异。 例如，在哺乳动物中，就存在多种 eIF4E 异构体，它们各自在不同组织和细胞类型中发挥特定的功能。

胃癌是常见恶性肿瘤。研究人员开展 PRSS23 参与胃癌发生发展机制的研究，发现 PRSS23 通过调节 eIF4E-c-Myc 轴影响胃癌生长，高表达与不良预后相关。该轴有望成为胃癌治疗靶点，为攻克胃癌带来新希望。

例如，通过抑制eIF4E与帽端的结合或干扰eIF4A的“清道夫”功能，可以有效阻断癌细胞对翻译起始过程的依赖，从而抑制肿瘤的生长。

例如，通过抑制eIF4E与帽端的结合或干扰eIF4A的“清道夫”功能，可以有效阻断癌细胞对翻译起始过程的依赖，从而抑制肿瘤的生长。

The eukaryotic translation-initiation factor eIF4E is a rate-limiting factor in protein translation. Sonenberg and colleagues show that phosphorylation of eIF4E modulates the antiviral response by ...

Increased melanoma expression of eIF4E and phospho-eIF4E is associated with metastatic potential, reduced survival and increased risk of death.

PURPOSE: Complete excision of cancer is guided by histologic assessment of surgical margins. Molecular markers may be more sensitive in identifying malignant cells. eIF4E, a eukaryotic protein ...

Additionally, eIF4E is also central to many resistance mechanisms, therefore eIF4E inhibition has the potential to overcome drug resistance and re-sensitize tumors to anti-cancer therapies.

The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well ...

eIF4E-mediated recessive resistance against potyviruses More than half of the known resistance genes for potyviruses behave in a recessive manner.

Additionally, eIF4E is also central to many resistance mechanisms, therefore eIF4E inhibition has the potential to overcome drug resistance and re-sensitize tumors to anti-cancer therapies.