本研究针对eIF4E过表达在多种肿瘤中的关键作用，设计合成42种新型肼基噻唑衍生物（A1-A42），其中化合物A37通过抑制Ras/MAPK/eIF4E信号通路、诱导凋亡及抑制迁移，在体外和HepG2裸鼠移植瘤模型中均表现出高效低毒的抗癌特性，为靶向eIF4E/eIF4G相互作用的临床转化提供新策略。

Gemin5 and eIF4E co-localized to cytoplasmic P-bodies in human osteosarcoma U2OS cells. Interaction between eIF4E and Gemin5 and their co-localization to the P-bodies, may serve to recruit capped ...

Cytoplasmic FMRP interacting protein 1 (CYFIP1), also known as specifically RAC1 activated protein 1 (Sra1), plays a dual role: together with fragile X mental retardation protein (FMRP) and eIF4E it ...

The synthetic lethality between eIF2A and eIF4E (Komar et al., 2005) is interesting in this regard since eIF4E is also involved in the nuclear export of transcripts with 4E-SE elements. This raises ...

mTOR and EIF4E pathways mTOR is a key protein that regulates cell growth and protein production. EIF4E is part of the machinery that starts translating RNA into protein. Disruptions in these pathways ...

Translation initiation in eukaryotes requires a 40 S ribosome loaded with initiator tRNA which scans for an initiation codon. The initiator tRNA is usually recruited to the ribosome as part of a ...

在STHdh Q7/Q7 纹状体细胞中，HA-4E-BP1 F113A 转染24小时后通过免疫共沉淀证实其与eIF4E结合能力增强，伴随嘌呤霉素掺入量减少。 原代神经元感染AAV-4E-BP1 F113A 7天后，同样观察到翻译抑制效应，证实该突变体在体外具有预期功能。

We show that ANGEL2 directly interacts with eukaryotic translation initiation factor 4E (EIF4E), the rate-limiting protein in cap-dependent translation. This interaction abrogates the ability of the ...

Among other functions, mTOR phosphorylates proteins involved in translation regulation including S6K and 4E-BP1 (eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1). This mTOR ...

本研究探索了由eIF2B活性降低引发的机制，它与c-ISR不同，证明了哺乳动物ISR的可塑性，即在未诱导eIF2α-p的情况下eIF2B活性的丧失会激活eIF4E-ATF4-PCK2 ...