This protein associates with mRNAs containing the eIF4E‐sensitivity element (4E‐SE), and its overexpression alters the nuclear export of several eIF4E‐sensitive mRNAs. LRPPRC‐mediated alteration of ...

Among other functions, mTOR phosphorylates proteins involved in translation regulation including S6K and 4E-BP1 (eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1). This mTOR ...

Gemin5 and eIF4E co-localized to cytoplasmic P-bodies in human osteosarcoma U2OS cells. Interaction between eIF4E and Gemin5 and their co-localization to the P-bodies, may serve to recruit capped ...

Cytoplasmic FMRP interacting protein 1 (CYFIP1), also known as specifically RAC1 activated protein 1 (Sra1), plays a dual role: together with fragile X mental retardation protein (FMRP) and eIF4E it ...

mTOR and EIF4E pathways mTOR is a key protein that regulates cell growth and protein production. EIF4E is part of the machinery that starts translating RNA into protein. Disruptions in these pathways ...

Expression of eIF4e-BP1 induces apoptosis, whereas ectopic expression of eIF4e is oncogenic, provides protection from apoptosis and cooperates with MYC in lymphomagenesis. eIF4e is also a critical ...