eIF4E 家族的自然多样性 在众多真核生物中，eIF4E 异构体存在广泛的自然多样性。 不同物种的 eIF4E 异构体在氨基酸序列、表达水平和组织分布上都有所差异。 例如，在哺乳动物中，就存在多种 eIF4E 异构体，它们各自在不同组织和细胞类型中发挥特定的功能。

Despite its importance as a therapeutic target, little is understood about the effects of modulating eIF4E on global translation and cancerous phenotypes, (17) largely because scientists have lacked ...

胃癌是常见恶性肿瘤。研究人员开展 PRSS23 参与胃癌发生发展机制的研究，发现 PRSS23 通过调节 eIF4E-c-Myc 轴影响胃癌生长，高表达与不良预后相关。该轴有望成为胃癌治疗靶点，为攻克胃癌带来新希望。 胃癌是最常见的恶性肿瘤 ...

DURHAM, N.C., September 16, 2024--Ribometrix, a biotechnology company developing small molecule therapeutics that modulate RNA biology, presented the latest data from its eIF4E program at the ...

Targeting eIF4E has the potential to enhance anti-cancer activity when given in combination with standard-of-care. Additionally, eIF4E inhibition has the potential to overcome drug resistance and ...

Additionally, eIF4E inhibition has the potential to overcome drug resistance and re-sensitize tumors to anti-cancer therapies. Based on substantial external and in-house data, Ribometrix is developing ...

在抗病西瓜种质PI 244019中过表达感病西瓜eIF4E（CleIF4EWT）可以打破PI 244019对PRSV和ZYMV的抗性，而过表达抗病西瓜eIF4E（CleIF4ED71G）则不能。 因此，G71是决定西瓜种质PI 244019抗PRSV和ZYMV的关键氨基酸位点。 此外，作者还发现氨基酸残基D71在植物eIF4E中相对保守。

About eIF4E Eukaryotic translation initiation factor 4E (eIF4E), the main regulatory component of cap-dependent mRNA translation, selectively promotes pro-oncogenic protein synthesis in response to ...

NATICK, Mass.-- (BUSINESS WIRE)--PIC Therapeutics, Inc., a biotechnology company pioneering the discovery and development of first-in-mechanism, first-in-class allosteric small molecule therapies ...

Acceptance summary: The authors present convincing evidence that the interactions of eIF4A and eIF4E with Ded1 are critical in vivo in yeast. They delineated the locations in Ded1 of the binding sites ...

真核翻译起始因子4E（eIF4E）抑制剂可逆地结合eIF4E并带负电荷，去除负电荷会导致结合亲和力急剧下降。 eIF4E的结合位点有可被共价靶向的赖氨酸，因此，利用共价抑制剂高亲和力和强选择性的特点来解决现有eIF4E抑制剂无细胞活性的问题有一定的可行性。