About eIF4E. Eukaryotic translation initiation factor 4E (eIF4E), the main regulatory component of cap-dependent mRNA translation, selectively promotes pro-oncogenic protein synthesis in response ...

PIC Therapeutics is therefore uniquely positioned to therapeutically address eIF4E as one of the key drivers of cancer cell survival, uncovering unique mechanisms that may be harnessed for ER+ ...

胃癌是常见恶性肿瘤。研究人员开展 PRSS23 参与胃癌发生发展机制的研究，发现 PRSS23 通过调节 eIF4E-c-Myc 轴影响胃癌生长，高表达与不良预后相关。该轴有望成为胃癌治疗靶点，为攻克胃癌带来新希望。 胃癌是最常见的恶性肿瘤 ...

研究发现，eIF4E与帽端的结合可以通过eIF4G进一步稳定，同时引导eIF4A在正确的区域展开解旋活动。 而这种协作不仅提高了翻译效率，也赋予了翻译 ...

研究发现，eIF4E与帽端的结合可以通过eIF4G进一步稳定，同时引导eIF4A在正确的区域展开解旋活动。 而这种协作不仅提高了翻译效率，也赋予了翻译 ...

The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well as others.

eIF4E 家族在真核生物的翻译起始过程中具有重要地位，其蛋白质多样性体现在不同生物体的异构体差异、结构特点以及功能的多样性上。eIF4E 在肿瘤发生、应激反应和病毒感染等过程中都发挥着关键作用，同时，其功能受到多种精细调控机制的调节。

Several investigations on crop and model plants have confirmed that VPg-eIF4E/(iso)4E interaction is necessary for potyvirus infection. We investigated the functions of the VPg-eIF(iso)4E interaction ...

Increased eIF4E and phospho-eIF4E expression was highly associated with malignancy (P<0.0001). High nuclear phospho-eIF4E was associated with synchronous or future metastasis (P=0.0059).

The eukaryotic translation-initiation factor eIF4E is a rate-limiting factor in protein translation. Sonenberg and colleagues show that phosphorylation of eIF4E modulates the antiviral response by ...

RESULTS: All 65 patients had elevated levels of eIF4E in the tumors. Thirty-six patients (55%) had elevated eIF4E in histologically tumor-free margins, and 20 of these patients (56%) have had ...