值得注意的是，肽16AC能增强BM血浆的促增殖作用，而肽6对其影响有限，暗示BM血浆的促血管生成效应可能通过非heparanase-TF通路实现。 这项研究首次阐明骨髓微循环通过维持低heparanase-TF活性创造利于骨再生的微环境，同时通过独立机制促进血管新生。

The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably metastatic tumor cells and migrating leukocytes. Here we report the cDNA ...

Heparanase levels were significantly elevated in tongue cancer patients, suggesting that it might be useful as a diagnostic tool to monitor progression of this disease and response to treatment.

Synthetic heparanase inhibitors: Research team develops alternative method for the treatment of herpes by Geert-Jan Boons, Wiley Editors' notes ...

Heparanase in myeloma related renal dysfunction: Role in promoting nephrotoxicity and potential as a novel biomarker for early detection.

A research team from China developed short hairpin RNA against heparanase (HPA), and determined its effects on HPA expression and the malignant characteristics of gastric cancer cells. Their study ...

While more research is needed to understand the most effective way of inhibiting heparanase to prevent viral reinfections, these findings indicate that blocking the protein could be a promising ...

Keeping herpes in check Synthetic heparanase inhibitors inhibit the spread of herpes viruses in tissue Date: September 7, 2023 Source: Wiley Summary: Herpes is not only unpleasant but it can, in ...

Researchers at Radboud University Medical Center in the Netherlands reported an increase of heparanase activity and heparan sulfate levels in the plasma of patients with coronavirus disease (COVID ...

Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of gastric cancers. Although their efficiencies in inhibiting the ...