The endoglycosidase heparanase is an important in the degradation of the extracellular matrix by invading cells, notably metastatic tumor cells and migrating leukocytes. Here we report the cDNA ...

Heparanase, the sole mammalian enzyme capable of cleaving heparan sulphate chains, is emerging as a central regulator of extracellular matrix (ECM) dynamics.

Heparanase (HPSE), a glycoside hydrolase that cleaves heparan sulfate chains, plays a crucial role in cancer progression by remodeling the extracellular matrix and facilitating tumor metastasis. This ...

研究发现，两种病毒共同激活Heparanase（HPSE）——一种切割硫酸乙酰肝素（HS）的内切糖苷酶，导致内皮功能障碍和血栓形成。 动物实验表明，HPSE抑制剂（如低分子肝素LMWH）可降低共感染并发症风险，而HS模拟物Pixatimod能阻断TLR4介导的巨噬细胞极化。

Scientists identified the mechanism by which a sea cucumber molecule inhibits sulfatase-2, an enzyme that’s often upregulated ...

Although diverse cell penetrating motifs not only from naturally occurring proteins but also from synthetic peptides have been discovered and developed, the selectivity of cargo delivery connected to ...

Heparanase, for instance, was shown to be abundant in the colonic epithelium of patients with IBD in contrast to normal colonic tissue or colonic tissue afflicted by infectious colitis, 21 and its ...

Akt isoforms are generally considered functionally redundant, contributing to total Akt activity. However, during HSV-1 infection, Akt1 and Akt2 kn ...

Lymphedema is a prevalent, incurable, and morbid condition with the potential to degrade the health and quality of life of patients living with cancer and beyond cancer. Effective long term control ...