Heparanase levels were significantly elevated in tongue cancer patients, suggesting that it might be useful as a diagnostic tool to monitor progression of this disease and response to treatment.

In addition, inhibition of heparanase through the new inhibitors can impede the migration and proliferation of immortalized cells (that is, cells with uncontrolled cell growth).

This is why researchers hypothesized that heparanase contributes to the pathogenesis of COVID-19 and that heparan sulfate may be inhibited with the use of low molecular weight heparins.

Ralph Sanderson. Ph.D., Endowed Professor of Cancer Pathobiology and Division Director, Molecular and Cellular Pathology, recently co-authored and edited the book Heparanase along with Israel ...

One of these, heparanase (encoded by HPSE), is the only known mammalian endoglycosidase that can efficiently degrade the HS side chains of HSPGs, the team continues.

The UIC team examined how the heparanase protein, which is present in all our cells, affects reinfection from the herpes simplex virus type 1 in mice. They found that inhibiting heparanase ...

Previous studies have indicated that the heparanase (HPA) is correlated with histopathological parameters and poor prognosis of gastric cancers. Although their efficiencies in inhibiting the ...

A research team from China developed short hairpin RNA against heparanase (HPA), and determined its effects on HPA expression and the malignant characteristics of gastric cancer cells. Their study ...

Synthetic heparanase inhibitors inhibit the spread of herpes viruses in tissue Date: September 7, 2023 Source: Wiley Summary: Herpes is not only unpleasant but it can, in some cases, also have ...

This is achieved using a ‘heparanase inhibitor’. Heparanase acts likes a pair of scissors, damaging the glycocalyx lining. Heparanase inhibitors stop this damage from happening. The research team has ...