Background: The Homeobox (HOX) gene family are conserved transcription factors that are essential for embryonic development, oncogenesis, and cancer suppression in biological beings. Abnormally ...

A research team has identified the transcription factor Lhx2 (LIM homeobox protein 2) as a key regulator in hepatic stellate cells. Lhx2 was found to simultaneously promote liver regeneration and ...

A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the ...

The new drug candidate for FSHD will combine an RNA molecule from miRecule targeting double homeobox 4 (DUX4) – a protein that is mutated in FSHD – with a nanobody developed by Sanofi that ...

团队前期研究表明，MSX1可通过直接结合增强子II/核心启动子（EnII/Cp）并抑制其启动子和增强子活性来抑制HBV的基因表达和复制。除了上述调控机制外，MSX1还在转录后水平下调HBx蛋白的稳定性，且不受HBX基因型的影响。进一步证实，MSX1通 ...

The responsible metabolic lesion appears to involve a posttranscriptional defect in pancreas duodenum homeobox-1 (PDX-1) mRNA maturation. PDX-1 is a critically important transcription factor for ...

We describe two patients in whom malignant monoclonal T-cell lymphoproliferation developed after administration of chimeric antigen receptor (CAR) T-cell therapy with ciltacabtagene autoleucel ...

引言在生命科学领域，细胞身份（cell identity）的稳定性始终是个迷人而危险的谜题。就像精密运作的宇宙飞船需要严格的门禁系统，每个细胞都携带着决定其功能的基因密码。但当这种"基因门禁"失效时，细胞会陷入身份混乱——这正是癌症发生的核心机制之一 ...

Guardians undermine cancer drivers The research team found almost 30 different guardian candidates and decided to pursue one ...