药筛抗生素在筛选稳转细胞株以及基因编辑转染实验中会经常用到，它们能够杀死未转染或未整合抗性基因的细胞，从而使得带有抗性基因的细胞得以生长和扩增。常用的药筛抗生素主要包括以下几类： ...

This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

引言在生命的微观剧场中，RNA分子如同精准的时空指挥官，通过动态的定位与运输调控基因表达、蛋白质合成乃至细胞命运。然而，研究人员长久以来只能通过"静态快照"（如固定细胞成像）或"人工标记"（如插入荧光标记序列）来推测这些分子的行为，就像通过化石拼凑恐 ...

Louis, MO, USA). LAD2 cells were transduced with polybrene 8 µg/ml (Santa Cruz) and selected with puromycin 1µg/ml. Cells were maintained with puromycin until the day of the experiment, when it was ...

Endometriosis is a common gynecological disease, characterized by the presence of endometrial-like lesions outside the uterus. This debilitating disease causes chronic pelvic pain and infertility with ...

引言在我们体内，数以亿计的细胞每天都在进行着极其复杂的生命活动，其中翻译过程扮演着至关重要的角色。翻译是基因表达的最后一步，它通过核糖体（ribosome）将mRNA上的遗传信息转化为蛋白质，驱动细胞的功能。然而，尽管翻译过程已经被广泛研究，研究人员却一直未能完全解开一个关键谜团：多个核糖体如何协同工作来高效地 ...

Objectives To investigate the effect of the L-arginine metabolism on arthritis and inflammation-mediated bone loss. Methods L-arginine was applied to three arthritis models (collagen-induced arthritis ...

为解决肝癌治疗难题，复旦大学附属肿瘤医院的研究人员开展 FAM99B 相关研究。发现 FAM99B 可抑制核糖体生成和肝癌进展，GalNAc - FAM99B65 - 146 有治疗潜力。该研究为肝癌治疗提供新思路，值得科研人员阅读。