ABSTRACT: Currently, no clinically approved therapeutic drugs specifically target dengue virus infections. This study aims to evaluate the potential of antiviral drugs originally developed for other ...

Their capsid proteins share homology with the RNA virus tombusvirus, while their replicase-associated proteins are homologous to a class of single-stranded DNA viruses, namely CRESS DNA viruses. This ...

Now, a tool known as RNA replicase-assisted continuous evolution (REPLACE) enables directed evolution in mammalian cells via mutagenesis and amplification of RNA and selection for desired phenotypes.

Nucleic acid amplification techniques currently available or under active development include the polymerase chain reaction (PCR), the ligase chain reaction (LCR), transcription based amplification ...

It is widely recognized that TNTs play a crucial role in facilitating the rapid cell-to-cell transmission of viruses. These structures transport various viral components, including virions, viral ...

The leading data integration platform for ETL / ELT data pipelines from APIs, databases & files to data warehouses, data lakes & data lakehouses. Both self-hosted and Cloud-hosted.

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

The leading data integration platform for ETL / ELT data pipelines from APIs, databases & files to data warehouses, data lakes & data lakehouses. Both self-hosted and Cloud-hosted.

RNA-based therapeutics have rapidly emerged over the past decade, offering a new class of medicines that differ significantly from conventional drugs. These therapies can be programmed to target or ...

Department of Chemistry, New York University, New York, New York 10003, United States Department of Chemistry, New York University, New York, New York 10003, United States Courant Institute of ...