The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress responses alter the ...

Turtles, known for their long lives and large bodies, rarely develop cancer, a trait that researchers now say makes them ...

Hemifusomes are fused vesicles, or sacs of fluid, that were previously unknown to exist inside cells. They were discovered ...

A further understanding of the organelle could pave the way for better treatment of genetic and neurodegenerative diseases.

Diabetic cardiomyopathy (DCM) is a critical complication of diabetes, the accurate pathogenesis of which remains elusive. It is widely accepted that endoplasmic reticulum (ER) stress and abnormal ...

Letter Published: 03 July 1965 Effect of Electrical Stimulation on Uptake and Release of Calcium by the Endoplasmic Reticulum KWANG SOO LEE Nature 207, 85–86 (1965) Cite this article ...

Scientists at the University of Western Australia and the Perron Institute for Neurological and Translational Science have ...

SGT-501 is a novel gene therapy for rare, life-threatening, genetic arrhythmogenic disease with no approved therapies - - SGT-501 has received Orphan Drug Designation and Rare Pediatric Disease Design ...

引言病毒，这些微小的生命形式，是地球上最古老、最成功的“入侵者”。当它们潜入我们的细胞，一场无声的战争便拉开序幕。我们的身体拥有一套复杂而高效的防御体系——免疫系统，它如同一个国家的军队，时刻准备着识别并消灭敌人。面对病毒感染，细胞通常有两条主要的应 ...

BACKGROUND: Pathological cardiac remodeling after myocardial infarction (MI) is a leading cause of heart failure and sudden death. The detailed mechanisms underlying the transition to heart failure ...

Background Methyl donor deficiency (MDD) aggravates experimental colitis in rats and increases endoplasmic reticulum (ER) stress through decreased sirtuin 1 (SIRT1) in neuronal cells and myocardium.

The reticulum is a pouch-like structure in the forward area of the body, close to the heart. The tissues in the reticulum form a network similar to a honeycomb. A small tissue fold lies between the ...