The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress responses alter the ...

The endoplasmic reticulum (ER)-localized transmembrane proteins IRE1, PERK and ATF6 detect the load of unfolded protein in the lumen of the organelle, serving as stress receptors. They transduce ...

Charlestown, Massachusetts Thursday, July 10, 2025, 15:30 Hrs [IST] ...

A further understanding of the organelle could pave the way for better treatment of genetic and neurodegenerative diseases.

Hemifusomes are fused vesicles, or sacs of fluid, that were previously unknown to exist inside cells. They were discovered ...

Turtles, known for their long lives and large bodies, rarely develop cancer, a trait that researchers now say makes them ...

Diabetic cardiomyopathy (DCM) is a critical complication of diabetes, the accurate pathogenesis of which remains elusive. It is widely accepted that endoplasmic reticulum (ER) stress and abnormal ...

The reticulum is a pouch-like structure in the forward area of the body, close to the heart. The tissues in the reticulum form a network similar to a honeycomb. A small tissue fold lies between the ...

Background Methyl donor deficiency (MDD) aggravates experimental colitis in rats and increases endoplasmic reticulum (ER) stress through decreased sirtuin 1 (SIRT1) in neuronal cells and myocardium.

Scientists at the University of Western Australia and the Perron Institute for Neurological and Translational Science have ...

University of Western Australia research reveals how cells convert physical exercise forces into energy production responses.

Scientists have made a groundbreaking discovery in the realm of human cell biology. Through the use of cryo-electron ...