Objectives To assess the diagnosis of somatic symptom disorder (SSD) in patients with unexplained neurological symptoms occurring after SARS-CoV-2 infection, also referred to as long COVID. Design ...

Background Benign multiple sclerosis (MS), characterised by minimal disability despite long disease duration, remains poorly understood in terms of its determinants and prognostic implications. While ...

Background Amyloid-related imaging abnormalities due to oedema (ARIA-E) or haemosiderin deposits (ARIA-H) have been associated with the use of monoclonal antibodies, such as lecanemab, for the ...

Frontal lobe brain sagging syndrome is recently described syndrome, though its natural history and pro- gression remains unknown. We present a 68-year-old female with progressive worsening of ...

Background Evidence of best practice for long term physical activity Huntington’s disease (HD) is lacking, due in part, to inherent challenges in the delivery and evaluation of such life-style ...

Biography Dr Lucy Vanes is a lecturer in Neuroscience and Psychology at the Department of Neuroimaging, King’s College London. She completed her PhD in 2017, studying the neural correlates of ...

Background Pain is an important symptom in Huntington’s disease (HD), however, not systematically studied and understood. The objective of the current study is to assess the prevalence of pain, pain ...

Enroll-HD is a global research platform. Key elements of the platform’s infrastructure include global study management and governance, standardised informed consent forms (ICFs) and site contracts, ...

Benign positional vertigo (BPV) is the most frequent cause of vertigo seen in office practice, with a lifetime incidence of at least 8%.1 While most patients give a diagnostic history—brief spinning ...

Hereditary proximal spinal muscular atrophy (SMA) is caused by survival motor neuron (SMN) protein deficiency due to homozygous loss of SMN1 gene function. Residual SMN protein levels are produced by ...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the loss of both upper and lower motor neurons. Approximately 10% of patients with ALS have a family history of the ...

Conclusions In this large dataset, optimal MACE cut-offs for dementia and MCI differed from the index study reflecting the different casemix of the studies. Revision of MACE cut-offs in may be ...