Introduction COPD is a heterogeneous disorder with varied phenotypes. We aimed to determine the prevalence of asthma history, peripheral eosinophilia and elevated FeNO levels along with the diagnostic ...

Introduction A gap exists in the literature regarding dose–response associations of objectively assessed housing quality measures, particularly dampness and mould, with hospitalisation for acute ...

INTRODUCTION Community-acquired pneumonia (CAP) is the leading cause of infectious death globally 1 2 and disproportionately affects those at the extremes of age. CAP is one of the leading causes of ...

Background Coding practices impact the recorded prevalence of disease. Sepsis, most commonly caused by pneumonia, remains a common cause of mortality worldwide. In April 2017, NHS Digital issued new ...

The following is a summary of the British Thoracic Society (BTS) Guideline for diagnosing and monitoring paediatric sleep-disordered breathing (SDB) and includes a summary of the recommendations and ...

The 2020 coronavirus pandemic has been particularly difficult for people living with chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD). COPD is associated with ...

Introduction Low-dose CT (LDCT) screening of high-risk smokers reduces lung cancer (LC) specific mortality. Determining screening eligibility using individualised risk may improve screening ...

Method Adults with a first-recorded code for breathlessness (index date) and subsequent coded diagnosis between 2007 and 2017 were included from a UK primary care database (CPRD-GOLD). Cox regression ...

Introduction Fibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the key effector cells responsible ...

Introduction Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant proportion of people with severe asthma (SA). Despite the effectiveness of anti-IL5/5R therapies in the ...

Background Randomised controlled trials (RCTs) of vitamin D to prevent COPD exacerbations have yielded conflicting results. Individual participant data meta-analysis could identify factors that ...

Background Up to 50% of patients suffering acute pulmonary embolism (PE) demonstrate impaired pulmonary vascular recovery at follow up despite optimal anticoagulation, impacting negatively on ...