Copine-6, also known as N-Copine (Neuronal-Copine), is a calcium-dependent phospholipid-binding protein of the Copine family (Copine 1–9, coded for by Cpne1-9 genes) (Creutz et al, 1998; Khvotchev and ...

Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Although the Arabidopsis thaliana RPD3-type histone deacetylase HDA19 and its close homolog HDA6 participate in SIN3-type histone deacetylase complexes, they display distinct biological roles, with ...

EMBO Press publishes five scientific journals: The EMBO Journal - Submit here The EMBO Journal has been EMBO's flagship publication for 40 years. With a scope that spans all areas of molecular biology ...

Clear-cell renal cell carcinoma (ccRCC) poses a significant challenge in cancer treatment, with high rates of resistance to radio and chemotherapy and poor patients’ outcomes at late diagnosis. The ...

This review investigates the role of neuronal epigenomes as molecular mediators of brain aging and potential targets to prevent cognitive decline. It first discusses the current evidence for neuronal ...

Artificial sweeteners (AS), also known as non‐nutritive or non‐caloric sweeteners, are compounds that demonstrate significantly higher sweetening power when compared to sucrose. Their caloric ...

ITM2B/BRI2 mutations cause Alzheimer’s Disease (AD)-related dementias. We observe heightened ITM2B/BRI2 expression in microglia, a pivotal cell type in AD due to risk-increasing variants in the ...

Lgr5 + intestinal stem cells (ISCs) are crucial for the intestinal epithelium renewal and regeneration after injury. However, the mechanism underlying the interplay between Wnt and BMP signaling in ...

One example of the PCNA-coordinated process is the lagging strand maturation, which involves at least four PCNA-interacting enzymes, Pol δ, RNaseH2 (Ribonuclease H2), FEN1 (Flap endonuclease 1), and ...

Secretion systems play a crucial role in microbe-microbe or host-microbe interactions. Among these systems, the extracellular contractile injection system (eCIS) is a unique bacterial and archaeal ...

While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate ...