Fragile X disorders include two distinct conditions: fragile X syndrome (the most common single-gene cause of developmental delay and autism) and an entirely separate group of premutation syndromes.

In the current anti-immigrant political environment in the United States, what will happen when immigrants who work in the health care system are forced to leave?

Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular reocclusion may occur after intravenous thrombolysis and may be preventable ...

Explore this issue of The New England Journal of Medicine (Vol. 0 No. 0).

At first glance, China might seem unlikely to offer useful health care lessons to other countries. But China has undertaken a series of remarkable health system experiments that are instructive at ...

Explore the current issue of The New England Journal of Medicine (Vol. 393 No. 2).

As-needed fixed-dose albuterol–budesonide may lower the risk of severe asthma exacerbations, as compared with as-needed albuterol alone, in patients with uncontrolled disease despite treatment ...

A 61-year-old man presented with hypoxemic respiratory failure and shock 10 weeks after kidney transplantation. A purpuric rash was present on the abdomen. A diagnosis was made.

After decades of undergoing epidemiologic study, prostate cancer remains an enigmatic disease; the only established risk factors are older age, family history of prostate cancer, and African ancest ...

This editorial explains the genetic basis of Pompe’s disease and other lysosomal storage disorders, as well as the foundations of enzyme-replacement therapy.

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