Many neurological diseases are caused by pathogenic unstable intragenic trinucleotide repeat (TNR) expansions, such as the GAA trinucleotide repeat within the FXN gene in Friedreich ataxia (FRDA ...

The secondary structure of repeated trinucleotide sequences results in the development of several neurodegenerative diseases, and these studies consider the (CAG)8 sequence that forms a stem−loop ...

The reaction of low-energy electrons (LEEs; 10 eV) with 5′-TpXpT-3′ (TXT), where X is uracil (U), thymine (T), and 5-bromouracil (5BrU), was examined by HPLC-UV analysis. The presence of 5BrU ...

Researchers have found that cannabidiol (CBD) significantly reduces seizures and extends survival in a mouse model of ...

Friedreich ataxia, an autosomal recessive neurodegenerative disease, is the most common of the inherited ataxias. The recent discovery of the gene that is mutated in this condition, FRDA , has led to ...

In a clinical report issued by the American Academy of Pediatrics and published online June 23 in Pediatrics, guidance is ...

Scientists have created an artificial RNA system that can copy itself using simple building blocks and temperature changes.

Guidance from the American Academy of Pediatrics covers multiple genetic testing approaches to diagnosing developmental delay ...

The subcellular localization of long non-coding RNAs (lncRNAs) is fundamental to understanding their functional roles in gene regulation and disease mechanisms. Existing prediction models typically ...

The consistently decreased incidence of cancer in patients with polyQ diseases suggests that a common mechanism protects against the development of cancer. This feature could be related to the ...