5月26日 《Nature Genetics》 最新发表的这项重磅研究 “Base editing of trinucleotide repeats that cause Huntington’s disease and Friedreich’s ataxia reduces somatic repeat ...

编辑推荐： 来自台湾阳明大学，美国斯坦福大学等处的研究人员发表了题为“Spt4 Is Selectively Required for Transcription of Extended Trinucleotide Repeats”的文章，利用表型筛选和RNA测序等技术，发现了一种新型转录机制，为亨廷顿舞蹈症等具有同样氨基酸特征的神经失序症的治疗提出了新思路，这一研究成果 ...

Trinucleotide duplex formation inside a confined nanospace under supercooled conditions Hiroyuki Arafune, Akira Yamaguchi, Manato Namekawa, Yusuke Sato, Tetsuji Itoh, Ryoko Yoshida & Norio Teramae ...

Bacteria possess an array of defenses against foreign invaders, including a broadly distributed bacteriophage defense system termed CBASS (cyclic oligonucleotide-based anti-phage signaling system). In ...

(Phys.org)—A study of more than 6,000 genes in a common species of yeast has identified the pathways that govern the instability of GAA/TTC repeats. In humans, the expansions of these repeats is ...

Studies Ask Why Trinucleotide Repeats Expand, How to Clamp Down on Them Tools 05 Mar 2007 Two papers last week addressed related puzzles in Huntington’s and related diseases, that is, why children of ...

The full mechanism underlying genetic anticipation is largely unknown, but the phenomenon has most notably been associated with a particular type of mutation, known as trinucleotide repeat expansions.

In the current study, a peptide-conjugated PNA with 19 CAG trinucleotide repeats was the most selective, but LNAs are a better bet for clinical applications because they are already in use in trials, ...

Early research shows that editing expanding trinucleotide repeats halts the lengthening process that causes neurological disease.