with ~50% of tumors showing complete necrosis in human pancreatic tumors harboring a G12D mutation xenografted into mice. SIL-204 administered subcutaneously inhibited tumor growth in mouse ...

In vivo, mubritinib efficiently crosses the blood-brain barrier and accumulates in the brain, leading to tumour growth suppression and increased lifespan in treated patient-derived xenografted mice ...

In this mini review the status, advantages, and disadvantages of large animal modeling of breast cancer (BC) will be discussed. While most older studies of large animal BC models utilized canine and ...

Neuroendocrine tumors (NETs) are well-differentiated, low proliferating neuroendocrine neoplasms (NENs) (1), most commonly arising from gastroenteropancreatic structures and the lung, although NEN ...

These names in the biotech sector are seeing a substantial increase in search activity today, as determined by InvestingChannel. They ...

9 Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China Objective Metastasis is the major cause of cancer death. However, what types of heterogenous cancer cells ...

in human pancreatic tumors harboring a G12D mutation xenografted into mice. SIL-204 administered subcutaneously inhibited tumor growth in mouse metastatic pancreatic orthotopic models. A single ...

SIL-204 reduced tumor growth by ~50% and caused complete necrosis in ~50% of human pancreatic tumors in mice models with G12D mutations. A single systemic dose of SIL-204 sustained effective drug ...

This valuable study investigated the role of PLECTIN, a cytoskeletal crosslinker protein, in hepatocellular carcinoma development and progression. Using a liver-specific Plectin knockout mouse model, ...