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In kinesin–ADP 5, similar to tubulin:kinesin–ATP 11, the nucleotide is bound by interactions with P-loop subdomain residues and by the completely conserved Switch2 N-terminal residue, Asp231.
英国药理学:小檗胺和瓦巴因靶向Na+K+- atp酶与索拉非尼协同抑制肝癌 多激酶抑制剂索拉非尼是治疗晚期肝细胞癌(HCC)的一线药物。然而,肝癌患者对 ...
In general, ATP concentrations must be maintained above 1 mM, with a high ATP/ADP.Pi ratio, in order to sustain the energy needed for RNA and nucleotide biosynthesis.
Researchers aim to apply these findings to produce more complex ATP- and ADP-coupled biomolecules to investigate their role and significance in cell function. “Our ultimate goal is to elucidate their ...
Mutations in the gene that encodes a protein called adenine nucleotide translocator ... generate most of the ATP needed to fuel body's cells and play an important role in high-energy demanding ...
When ATP or ADP were added, this further increased gripping and friction, indicating two mechanisms of motor-DNA interaction -- nucleotide-dependent and nucleotide-independent.