A promising strategy to reduce the impact of viral infectious diseases, such as influenza, is the use of attenuated, live viruses as vaccines. However, the usefulness of traditional live-attenuated ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causal agent of the coronavirus disease 2019 (COVID-19), has a polybasic cleavage motif in the spike (S) protein. This is ...

Reviews of Infectious Diseases, Vol. 5, No. 3, 1982 International Symposium on Measles Immunization (May - Jun., 1983), pp. 477-481 (5 pages) Further-attenuated strains of measles virus may be ...

Since the beginning of the COVID-19 pandemic, researchers have been working on mucosal vaccines that can be administered through the nose. Now, scientists in Berlin have developed a live attenuated ...

Background. Highly pathogenic avian influenza A(H5N1) causes severe infections in humans. We generated 2 influenza A(H5N1) live attenuated influenza vaccines for pandemic use (pLAIVs), but they failed ...

EV25 was generally well-tolerated and demonstrated a good safety profile, with no observable dose-dependent safety trends.

Use the tissue culture to grow new viruses. You are about to create a live-attenuated vaccine, which means that you need to alter a pathogen—in this case a measles virus—so that it will still invade ...

The efficacy of influenza vaccines may decline during years when the circulating viruses have antigenically drifted from those included in the vaccine. A total of 1247 persons were vaccinated between ...

Please provide your email address to receive an email when new articles are posted on . There are several challenges to implementing the live-attenuated, temperature-sensitive influenza vaccine ...

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